Diabetes
Diabetes is one kind of chronic body-wide immunity metabolic disease. There are two kinds of clinical diabetes, type 1 and type 2. The onset of the disease is related to heredity, autoimmunity and environmental factors.
The statistics from WHO IN 2008: The rate of people who suffer from diabetes has increased from 3.4%, 5 years ago to 10% in 2008 (Chinese living in America is 20%), among them 90 - 95% are type 2 diabetics.
1. Inherited genetic factors
World wide recognition: diabetes is a hereditary disease; the genetic research indicates that the incidence rate of diabetes has a remarkable difference between blood relatives and non-blood relatives. The former case is 5 times higher than the latter case. With diabetes type 1, the hereditary factor's relevance is 50%, but with diabetes type 2, the hereditary factor's relevance reaches above 90%, therefore, the hereditary factors which cause diabetes type 2 are more significant than with diabetes type1.
2. Mental factors
Research within recent decades has confirmed the role of mental factors in the occurrence and development of diabetes, and is thought to be related to an increase in the amount of secretion of growth hormones, norepinephrine, adrenal hormones, etc., brought on by increased levels of mental stress.
3. The obesity factor
Recently, it is thought that obesity is an important contributing factor; about 60-80% of adult diabetics were overweight before the onset of the disease. The extent of the obesity has a positive relationship with the morbidity of the diabetes. The basal research material indicates: the rate of muscles and lipids changes with the development of age and the reduction of physical activities gradually.
4. Hyperphagia in the long-term
If the patient has out of control hyperphagia, this could cause the insulin B cells to have decreased or inadequate functioning, causing the insulin producing cells to have to work harder, potentially leading to diabetes. It is now understood that factors such as improper eating habits and obesity are directly linked to the increased possibility of developing diabetes.
5. Infections
There is a remarkable relationship between juvenile diabetes and a virus infection, the infection will not cause diabetes by itself, meaning the diabetes exists, but the symptoms are not showing or the diabetes has not been diagnosed yet.
6. Pregnancy
It has been discovered that the number of times a woman has been pregnant has a positive correlation with the increased risks of developing diabetes. Multiple pregnancies will increase the genetic factors causing diabetes.
7. Specific genetic factors
It is now thought that diabetes is caused by a few specific damaged genes: type 1 diabetes-the HLA-D gene located in the 6th short arm chromosome is damaged; type 2 diabetes-insulin gene, insulin receptor, glucose lyase gene and mitochondria gene are damaged. Briefly, no matter which kind of diabetes, environmental factors, or virus infections, in the final analysis, the source of the disease is related to the damage to specific genes. In other words, diabetes is a genetic disease.
Recently, the advancement of the related research and gradual deeper understanding of the causes of diabetes can be attributed to the combination of the knowledge of molecular biology, use of the electron microscope ultrastructure, immunology, physiology and biochemistry, etc.; this has produced a deeper cognition of the pathogenesis of the disease.
The main causes for the development of type 2 diabetes are insulin resistance and insulin paracrisis, which are based on the damage to the autoimmunity B cells and gene defects. Most of the researchers think that the insulin resistance is caused by the primary abnormality, but it is believed that it is very possible these two causes can exist at the same time, while the only differences are in the expression and the effectiveness of these causes.
Comprehensively, the mechanism of the type 2 diabetic's blood glucose increased exists in two aspects dysbolism:
1. The abnormality of the pancreas B cells, even the large reduction of the B cells (which is related with glucose or glycolipid toxicity) causes insulin paracrisis, insulin hyposecretion.
2. The tissues which are sensitive to insulin, such as found in the liver, and muscles, can lead to insulin resistance.
In the biomedical field, it has been confirmed that stem cells are a kind of multiple differentiation potential cell, acting like "seeds", which (the autologous stem cells with a defined quantity) are implanted into the tissue of the pancreas, "the seeds" can be guided to differentiate and proliferate into insulin producing cells, replace the damaged insulin B cells and secrete the insulin in the microenvironment of the pancreatic tissue. It overcomes to major problems: 1) The cells of the donor organs are in short supply; 2) Immunological rejection, the safety is remarkably increased. The literature from various nations all demonstrate that the curative effects of the stem cell implantation procedure is obvious in a short period of time, and the desired results of halting or decreasing the need of diabetic medication, as well as the safety of the procedure is good, with no obvious complications or discomfort to the patient.
The roles of treating diabetes by the use of stem cells:
1. Replacing the function of the abnormal B cells, increasing the quantity of the cells, restoring the autologous B cells, increasing the sensibility of the B cells to insulin, making insulin secretion more stable, and correcting insulin paracrisis.
2. Stem cells can repair the insulin postreceptor defects; the gene expression of the implanted stem cells will be normal, which can produce multiple normal working proteins, so there will be a decrease in the effects of insulin resistant proteins.
3. Stem cells can secrete plenty of insulin-like growth factor, to protect the pancreas.
4. Mesenchymal stem cells have the function of immunoregulation, which can treat the immune attacks to the tissue and organs. The expression of the stem cell functioning will be applied and exerted thoroughly under the control of experienced clinical doctors.
Questions and Answers
Q: Can you use stem cells to treat diabetes?
A: Yes, Wu Stem Cells Medical Center has a special stem cell treatment plan for type 2 diabetes. As for type 1 diabetes, they are still in the process of developing a new therapy to treat this type of the disease effectively.
Q: Is it a requirement to be admitted to the medical center while undergoing the stem cell treatment for type 2 diabetes?
A: Yes, the patient needs to stay in their medical center for treatment. In general, one treatment period covers two to three weeks. One period of their stem cell treatment covers two implantations of stem cells. They encourage patients to stay with them for three weeks since it may result in a better treatment outcome. For whatever reason, if a patient chooses the two-week program, they will request that patient be admitted to the medical center on either a Sunday or Monday in order to better implement their treatment process.
Q: What kind of stem cells will be used for the stem cell treatment? What is the treatment plan in detail?
A: In their treatment plan they use a combination of mesenchymal stem cells (MSCs) with neural stem cells (NSCs). The patient will receive a total of two stem cell implantations. Each implantation will include MSCs delivered by use of an end intravenous infusion and NSCs via lumbar puncture. Other medications will be given during the treatment as well. The role of these medications includes:
1. Controlling the patient's condition as well as maintaining normal blood sugar levels;
2. Adjusting the stem cells in vivo, making the stem cells survive and express the due physiological actions.
Q: What are the mechanisms of the stem cells used in the treatment for diabetes?
A: The main role of the NSCs is to improve the domination of the pancreatic nerves.
The main role of the MSCs is to improve the functioning of the pancreas and liver, as described below:
1) Pancreas:
A. The MSCs can nourish and support Beta-cells and improve the functioning of the Beta-cells.
B. The MSCs can differentiate into pancreatic cells.
2) Liver:
A. The MSCs will be properly directed in the liver, nourishing the liver function and the target cells.
B. The MSCs will change the sensibility of the insulin receptors on the cells' surface, repair insulin post-receptor defects.
C. The MSCs will promote the glyconeogenesis and restrain gluconeogenesis in the liver cells.
Q: How about the medical effectiveness of the stem cell treatment for diabetes?
A: They have treated dozens of patients with type 2 diabetes, with the total effective ratio above 90%. The main medical effectiveness covers two aspects:
1. The blood sugar level can be much better controlled, as well as other complications resulting from the diabetes.
2. The dosage of insulin can be decreased gradually, even halted. Except for insulin, they do not suggest to stop taking other medications early, because the medications will stimulate the normal regenerative cells to produce insulin. After the stem cell treatment is completed, the effectiveness of these medications will be more obvious.
Q: What are the admission procedures at the medical center?
A: Their stem cell treatment for type 2 diabetes is a highly individualized therapy, taking into account the differences of each patient. Each patient will have their own medical treatment plan according to their individual condition. The patient is requested to provide their current condition and medical history. According to this information, we will make sure that the patient is suitable for their stem cell therapy and then propose the appropriate medical treatment plan and the expected treatment outcome. This includes two separate stem cell implantations, daily medication and a patient room that allows the patient to stay with up to two caregivers or family members.
The statistics from WHO IN 2008: The rate of people who suffer from diabetes has increased from 3.4%, 5 years ago to 10% in 2008 (Chinese living in America is 20%), among them 90 - 95% are type 2 diabetics.
1. Inherited genetic factors
World wide recognition: diabetes is a hereditary disease; the genetic research indicates that the incidence rate of diabetes has a remarkable difference between blood relatives and non-blood relatives. The former case is 5 times higher than the latter case. With diabetes type 1, the hereditary factor's relevance is 50%, but with diabetes type 2, the hereditary factor's relevance reaches above 90%, therefore, the hereditary factors which cause diabetes type 2 are more significant than with diabetes type1.
2. Mental factors
Research within recent decades has confirmed the role of mental factors in the occurrence and development of diabetes, and is thought to be related to an increase in the amount of secretion of growth hormones, norepinephrine, adrenal hormones, etc., brought on by increased levels of mental stress.
3. The obesity factor
Recently, it is thought that obesity is an important contributing factor; about 60-80% of adult diabetics were overweight before the onset of the disease. The extent of the obesity has a positive relationship with the morbidity of the diabetes. The basal research material indicates: the rate of muscles and lipids changes with the development of age and the reduction of physical activities gradually.
4. Hyperphagia in the long-term
If the patient has out of control hyperphagia, this could cause the insulin B cells to have decreased or inadequate functioning, causing the insulin producing cells to have to work harder, potentially leading to diabetes. It is now understood that factors such as improper eating habits and obesity are directly linked to the increased possibility of developing diabetes.
5. Infections
There is a remarkable relationship between juvenile diabetes and a virus infection, the infection will not cause diabetes by itself, meaning the diabetes exists, but the symptoms are not showing or the diabetes has not been diagnosed yet.
6. Pregnancy
It has been discovered that the number of times a woman has been pregnant has a positive correlation with the increased risks of developing diabetes. Multiple pregnancies will increase the genetic factors causing diabetes.
7. Specific genetic factors
It is now thought that diabetes is caused by a few specific damaged genes: type 1 diabetes-the HLA-D gene located in the 6th short arm chromosome is damaged; type 2 diabetes-insulin gene, insulin receptor, glucose lyase gene and mitochondria gene are damaged. Briefly, no matter which kind of diabetes, environmental factors, or virus infections, in the final analysis, the source of the disease is related to the damage to specific genes. In other words, diabetes is a genetic disease.
Recently, the advancement of the related research and gradual deeper understanding of the causes of diabetes can be attributed to the combination of the knowledge of molecular biology, use of the electron microscope ultrastructure, immunology, physiology and biochemistry, etc.; this has produced a deeper cognition of the pathogenesis of the disease.
The main causes for the development of type 2 diabetes are insulin resistance and insulin paracrisis, which are based on the damage to the autoimmunity B cells and gene defects. Most of the researchers think that the insulin resistance is caused by the primary abnormality, but it is believed that it is very possible these two causes can exist at the same time, while the only differences are in the expression and the effectiveness of these causes.
Comprehensively, the mechanism of the type 2 diabetic's blood glucose increased exists in two aspects dysbolism:
1. The abnormality of the pancreas B cells, even the large reduction of the B cells (which is related with glucose or glycolipid toxicity) causes insulin paracrisis, insulin hyposecretion.
2. The tissues which are sensitive to insulin, such as found in the liver, and muscles, can lead to insulin resistance.
In the biomedical field, it has been confirmed that stem cells are a kind of multiple differentiation potential cell, acting like "seeds", which (the autologous stem cells with a defined quantity) are implanted into the tissue of the pancreas, "the seeds" can be guided to differentiate and proliferate into insulin producing cells, replace the damaged insulin B cells and secrete the insulin in the microenvironment of the pancreatic tissue. It overcomes to major problems: 1) The cells of the donor organs are in short supply; 2) Immunological rejection, the safety is remarkably increased. The literature from various nations all demonstrate that the curative effects of the stem cell implantation procedure is obvious in a short period of time, and the desired results of halting or decreasing the need of diabetic medication, as well as the safety of the procedure is good, with no obvious complications or discomfort to the patient.
The roles of treating diabetes by the use of stem cells:
1. Replacing the function of the abnormal B cells, increasing the quantity of the cells, restoring the autologous B cells, increasing the sensibility of the B cells to insulin, making insulin secretion more stable, and correcting insulin paracrisis.
2. Stem cells can repair the insulin postreceptor defects; the gene expression of the implanted stem cells will be normal, which can produce multiple normal working proteins, so there will be a decrease in the effects of insulin resistant proteins.
3. Stem cells can secrete plenty of insulin-like growth factor, to protect the pancreas.
4. Mesenchymal stem cells have the function of immunoregulation, which can treat the immune attacks to the tissue and organs. The expression of the stem cell functioning will be applied and exerted thoroughly under the control of experienced clinical doctors.
Questions and Answers
Q: Can you use stem cells to treat diabetes?
A: Yes, Wu Stem Cells Medical Center has a special stem cell treatment plan for type 2 diabetes. As for type 1 diabetes, they are still in the process of developing a new therapy to treat this type of the disease effectively.
Q: Is it a requirement to be admitted to the medical center while undergoing the stem cell treatment for type 2 diabetes?
A: Yes, the patient needs to stay in their medical center for treatment. In general, one treatment period covers two to three weeks. One period of their stem cell treatment covers two implantations of stem cells. They encourage patients to stay with them for three weeks since it may result in a better treatment outcome. For whatever reason, if a patient chooses the two-week program, they will request that patient be admitted to the medical center on either a Sunday or Monday in order to better implement their treatment process.
Q: What kind of stem cells will be used for the stem cell treatment? What is the treatment plan in detail?
A: In their treatment plan they use a combination of mesenchymal stem cells (MSCs) with neural stem cells (NSCs). The patient will receive a total of two stem cell implantations. Each implantation will include MSCs delivered by use of an end intravenous infusion and NSCs via lumbar puncture. Other medications will be given during the treatment as well. The role of these medications includes:
1. Controlling the patient's condition as well as maintaining normal blood sugar levels;
2. Adjusting the stem cells in vivo, making the stem cells survive and express the due physiological actions.
Q: What are the mechanisms of the stem cells used in the treatment for diabetes?
A: The main role of the NSCs is to improve the domination of the pancreatic nerves.
The main role of the MSCs is to improve the functioning of the pancreas and liver, as described below:
1) Pancreas:
A. The MSCs can nourish and support Beta-cells and improve the functioning of the Beta-cells.
B. The MSCs can differentiate into pancreatic cells.
2) Liver:
A. The MSCs will be properly directed in the liver, nourishing the liver function and the target cells.
B. The MSCs will change the sensibility of the insulin receptors on the cells' surface, repair insulin post-receptor defects.
C. The MSCs will promote the glyconeogenesis and restrain gluconeogenesis in the liver cells.
Q: How about the medical effectiveness of the stem cell treatment for diabetes?
A: They have treated dozens of patients with type 2 diabetes, with the total effective ratio above 90%. The main medical effectiveness covers two aspects:
1. The blood sugar level can be much better controlled, as well as other complications resulting from the diabetes.
2. The dosage of insulin can be decreased gradually, even halted. Except for insulin, they do not suggest to stop taking other medications early, because the medications will stimulate the normal regenerative cells to produce insulin. After the stem cell treatment is completed, the effectiveness of these medications will be more obvious.
Q: What are the admission procedures at the medical center?
A: Their stem cell treatment for type 2 diabetes is a highly individualized therapy, taking into account the differences of each patient. Each patient will have their own medical treatment plan according to their individual condition. The patient is requested to provide their current condition and medical history. According to this information, we will make sure that the patient is suitable for their stem cell therapy and then propose the appropriate medical treatment plan and the expected treatment outcome. This includes two separate stem cell implantations, daily medication and a patient room that allows the patient to stay with up to two caregivers or family members.
